Chelidamic acid

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

Product Specifications

CAS Number

[138-60-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amino Acid Decarboxylase

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Chelidamic_acid.html

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C=C(C(O)=O)N1)=O)O

Molecular Formula

C7H5NO5

Molecular Weight

183.12

Precautions

H315, H319, H335

References & Citations

[1]Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13 (8) :837-55.|[2]Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39 (16) :3645-51.|[3]Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34 (23) :4145-50.