Propyphenazone
Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID) . Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity[1][2].
Product Specifications
CAS Number
479-92-5
Product Name Alternative
4-Isopropylantipyrine; Isopropylphenazone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Propyphenazone.html
Purity
99.85
Solubility
DMSO : ≥ 2.6 mg/mL
Smiles
O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C
Molecular Formula
C14H18N2O
Molecular Weight
230.31
Precautions
H302, H315, H319, H335
References & Citations
[1]F Burdan. Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol. Hum Exp Toxicol. 2004 May;23 (5) :235-44.|[2]Mohamed F Radwan, et al. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. ACS Med Chem Lett. 2014 Jun 23;5 (9) :983-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX
Available Sizes
Frequently Asked Questions
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