Propyphenazone

Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID) . Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[479-92-5]

Product Name Alternative

4-Isopropylantipyrine; Isopropylphenazone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Propyphenazone.html

Purity

99.85

Solubility

DMSO : ≥ 2.6 mg/mL

Smiles

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C

Molecular Formula

C14H18N2O

Molecular Weight

230.31

Precautions

H302, H315, H319, H335

References & Citations

[1]F Burdan. Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol. Hum Exp Toxicol. 2004 May;23 (5) :235-44.|[2]Mohamed F Radwan, et al. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. ACS Med Chem Lett. 2014 Jun 23;5 (9) :983-8.