NBDHEX
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor[1][2].
Product Specifications
CAS Number
787634-60-0
UNSPSC
12352005
Target
Apoptosis; Autophagy; Glutathione S-transferase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nbdhex.html
Purity
98.56
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OCCCCCCSC1=CC=C([N+]([O-])=O)C2=NON=C21
Molecular Formula
C12H15N3O4S
Molecular Weight
297.33
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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