PTP1B-IN-24

PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT[1].

Product Specifications

CAS Number

[2221707-61-3]

UNSPSC

12352005

Target

Akt; Insulin Receptor; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ptp1b-in-24.html

Purity

95.01

Solubility

10 mM in DMSO

Smiles

O=C(S/1)N(CC(NC2=CC=C(C)C=C2)=O)C(C1=C\C3=COC4=CC=CC=C4C3=O)=O

Molecular Formula

C22H16N2O5S

Molecular Weight

420.44

References & Citations

[1]Zheng Y, et al. New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation. Bioorg Chem. 2024 Feb;143:106985.