Mirogabalin besylate
Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
Product Specifications
CAS Number
1138245-21-2
Product Name Alternative
DS 5565 besylate
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Mirogabalin_besylate.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC=C1)(O)=O.OC(C[C@@]2([C@@]3([H])[C@@](CC(CC)=C3)([H])C2)CN)=O
Molecular Formula
C18H25NO5S
Molecular Weight
367.46
Precautions
H302, H315, H319
References & Citations
[1]Domon Y, et al. Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels. J Pharmacol Exp Ther. 2018 Jun;365 (3) :573-582.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Cell Commun Signal. 2024 Feb 1;22 (1) :92.|Brain Behav Immun. 2021 Jul:95:344-361.|Molecules. 2023 Nov 30;28 (23) :7862.|Pharmaceuticals (Basel) . 2022 Jan 13;15 (1) :88.|Pharmaceuticals (Basel) . 2023 Jul 19;16 (7) :1023.
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