Mirogabalin besylate

Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.

Product Specifications

CAS Number

[1138245-21-2]

Product Name Alternative

DS 5565 besylate

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Mirogabalin_besylate.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC=C1)(O)=O.OC(C[C@@]2([C@@]3([H])[C@@](CC(CC)=C3)([H])C2)CN)=O

Molecular Formula

C18H25NO5S

Molecular Weight

367.46

Precautions

H302, H315, H319

References & Citations

[1]Domon Y, et al. Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels. J Pharmacol Exp Ther. 2018 Jun;365 (3) :573-582.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Citation 01

Cell Commun Signal. 2024 Feb 1;22 (1) :92.|Brain Behav Immun. 2021 Jul:95:344-361.|Molecules. 2023 Nov 30;28 (23) :7862.|Pharmaceuticals (Basel) . 2022 Jan 13;15 (1) :88.|Pharmaceuticals (Basel) . 2023 Jul 19;16 (7) :1023.