RIPA-56
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome[1].
Product Specifications
CAS Number
[1956370-21-0]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/RIPA-56.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCC(C)(C)C(N(CC1=CC=CC=C1)O)=O
Molecular Formula
C13H19NO2
Molecular Weight
221.30
Precautions
H302, H312, H315, H319
References & Citations
[1]Ren Y, et al. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-InteractingProtein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem. 2017 Feb 9;60 (3) :972-986.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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