Bis-propargyl-PEG1

Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[40842-04-4]

UNSPSC

12352211

Hazard Statement

H226

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bis-propargyl-peg1.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CCOCCOCC#C

Molecular Formula

C8H10O2

Molecular Weight

138.16

Precautions

H226

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562