Ruxolitinib (Standard)
Ruxolitinib (Standard) is the analytical standard of Ruxolitinib. This product is intended for research and analytical applications. Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3].
Product Specifications
CAS Number
[941678-49-5]
Product Name Alternative
INCB18424 (Standard)
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; JAK; Mitophagy; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ruxolitinib-standard.html
Purity
99.74
Smiles
N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2
Molecular Formula
C17H18N6
Molecular Weight
306.37
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched
Available Sizes
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