Omecamtiv mecarbil-d8

Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.

Product Specifications

Product Name Alternative

CK-1827452-d8

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Myosin

Type

Isotope-Labeled Compounds

Related Pathways

Cytoskeleton; Others

Field of Research

Cardiovascular Disease

Purity

99.57

Solubility

10 mM in DMSO

Smiles

O=C(N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CC2=C(C(NC(NC3=CC=C(N=C3)C)=O)=CC=C2)F)OC

Molecular Formula

C20H16D8FN5O3

Molecular Weight

409.48

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1 (9) :472-7.|[3]Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.|[4]Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292 (9) :3768-3778.