Ro 18-3981

Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca2+ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (Vh=-20 mV: IC50=2.3 nM; Vh=-50 mV: IC50=100 nM) [1].

Product Specifications

CAS Number

[103295-92-7]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ro-18-3981.html

Smiles

O=C(C1=C(C)NC(C)=C(C(CS(=O)(NC(C)C)=O)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOCCC

Molecular Formula

C24H33N3O8S

Molecular Weight

523.60

References & Citations

[1]Holck M, et al. Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential‐dependent blockade by Ro 18–3981[J]. British journal of pharmacology, 1987, 91 (1) : 61-67.