Atenolol

Atenolol ((RS) -Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].

Product Specifications

CAS Number

[29122-68-7]

Product Name Alternative

(RS) -Atenolol

UNSPSC

12352005

Hazard Statement

H302, H319, H351, H362

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Endocrinology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/atenolol.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic)

Smiles

O=C(N)CC1=CC=C(OCC(O)CNC(C)C)C=C1

Molecular Formula

C14H22N2O3

Molecular Weight

266.34

Precautions

H302, H319, H351, H362

References & Citations

[1]Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17 (6) :425-460.|[2]Engel G, et al. (+/-) [125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317 (4) :277-285.|[3]Corsini A, et al. Effect of the nifedipine-atenolol association on arterial myocyte migration and proliferation. Pharmacol Res. 1993 May-Jun;27 (4) :299-307. |[4]Lorusso B, et al. Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro. Vascul Pharmacol. 2022 Oct;146:107110|[5]Shen FM, et al. Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin. 2005 Nov;26 (11) :1303-8.|[6]Gould S, et al. Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats. J Natl Cancer Inst. 2007 Nov 21;99 (22) :1724-8. |[7]Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81 (5) :399-404.