MHuwentoxin-IV
MHuwentoxin-IV is a naturally modified Huwentoxin-IV. mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mhuwentoxin-iv.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(CC(C)C)C(N[C@H](CCC(O)=O)C(NC(C(C)CC)C(N[C@H](CC1=CC=CC=C1)C(NC(CCCCN)C(NC(C)C(NC(CSSCC(C(NC(CO)C(NC(CCCNC(N)=N)C(NC(CCCCN)C(NC(C(O)C)C(NC(CCCNC(N)=N)C(NC2CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC(N)=O)C(N6[C@@H](CCC6)C(NC(CO)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CCC(N)=O)C(NC7CSSCC(C(NC(CCCCN)C(NC(CC8=CC=C(C=C8)O)C(NC(CCC(N)=O)C(NC(C(C)CC)C(N)=O)=O)=O)=O)=O)NC2=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(NC([C@H]9NC(CC9)=O)=O)CSSCC(C(NC(CCCCN)C(NC(CO)C(NC(CO)C(NC(CCCCN)C(NC(CC(C)C)C(NC5C(C)C)=O)=O)=O)=O)=O)=O)NC7=O
Molecular Formula
C174H276N52O50S6
Molecular Weight
4088.76
References & Citations
[1]Rong M, et al. Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel. PLoS One. 2013 Jun 24;8 (6) :e65984.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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