OD1
OD1 is a scorpion α-toxin that can be isolated from the venom of the Iranian yellow scorpion (Odonthobuthus doriae. OD1 is a modulator of mammalian Nav1.7 (EC50: 4.5 nM) [1][2].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/od1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)NC2=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC6=CC=C(C=C6)O)C(NCC(N[C@@H](CC(N)=O)C(N[C@H]7C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CSSC[C@@H](C(N[C@H]%10CC%11=CNC%12=CC=CC=C%11%12)=O)NC7=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N%13[C@@H](CCC%13)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N%14[C@@H](CCC%14)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N%15[C@@H](CCC%15)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%10=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(NCC(N[C@H]8CC%16=CC=C(C=C%16)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C308H466N90O95S8
Molecular Weight
7206.06
References & Citations
[1]Durek T, et al. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. ACS Chem Biol. 2013;8 (6) :1215-22.|[2]Salvage SC, et al. The β3-subunit modulates the effect of venom peptides ProTx-II and OD1 on NaV 1.7 gating. J Cell Physiol. 2023 Jun;238 (6) :1354-1367.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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