Meclizine (dihydrochloride)
Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].
Product Specifications
CAS Number
1104-22-9
Product Name Alternative
Meclozine (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H361
Target
Apoptosis; Histamine Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Meclizine-dihydrochloride.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 33.33 mg/mL
Smiles
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1.Cl.Cl
Molecular Formula
C25H29Cl3N2
Molecular Weight
463.87
Precautions
H302, H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Ren Fail. 2023 Dec;45 (1) :2230318.|Am J Obstet Gynecol. 2024 Jul;231 (1) :113.e1-113.e13.|J Biochem Mol Toxicol. 2025 Aug;39 (8) :e70420.
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