YM-201636

YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.

Product Specifications

CAS Number

[371942-69-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Influenza Virus; PI3K; PIKfyve

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ym-201636.html

Purity

98.05

Solubility

DMSO : ≥ 47 mg/mL

Smiles

O=C(NC1=CC=CC(C2=NC(N3CCOCC3)=C4OC5=NC=CC=C5C4=N2)=C1)C6=CC=C(N=C6)N

Molecular Formula

C25H21N7O3

Molecular Weight

467.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns (3,5) P (2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9 (2), 164-170.|[2]Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns (3,5) P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382 (3) :566-70.|[3]Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns (3,5) P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303 (4) :C436-46.|[4]Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7 (3) :e28659.|[5]Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns (3,5) P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382 (3) :566-70.