Anti-Human/Mouse GRP78 Antibody (N88)

Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation[1][2].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

Akt; HSP; Interleukin Related

Type

Inhibitory Antibodies

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-human-mouse-grp78-antibody-n88.html

Solubility

10 mM in DMSO

Smiles

[Anti-Human/MouseGRP78Antibody(N88)]

Molecular Weight

(150 kDa)

References & Citations

[1]Gunner CB, et al. An antibody that targets cell-surface glucose-regulated protein-78 inhibits expression of inflammatory cytokines and plasminogen activator inhibitors by macrophages. J Cell Biochem. 2023 May;124 (5) :743-752.|[2]Trink J, et al. Integrin β1/Cell Surface GRP78 Complex Regulates TGFβ1 and Its Profibrotic Effects in Response to High Glucose. Biomedicines. 2022 Sep 10;10 (9) :2247.|[3]de Ridder GG, et al. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res. 2012 Jun;22 (3) :225-35.