TS-2

TS-2 is a fluorescent ligand of c-Myc G4 with anticancer activity. TS-2 inhibits the growth of cancer cells and induces apoptosis of cancer cells by targeting the c-MYC oncogene promoter G4, causing transcriptional repression of the c-Myc oncogene[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; c-Myc; G-quadruplex

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ts-2.html

Concentration

10mM

Purity

98.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[N+]1=C(SC=C1)/C=C/C2=CC(C3=C4C=CC=C3)=C(C=C2)N4C5=CC=CC=C5.[I-]

Molecular Formula

C24H19IN2S

Molecular Weight

494.39

References & Citations

[1]Rui Wang, et al. "Development of a fluorescent ligand that specifically binds to the c-MYC G-quadruplex by migrating the benzene group on a carbazole-benzothiazolium scaffold." Bioorganic Chemistry (2024) : 107690.