TS-2
TS-2 is a fluorescent ligand of c-Myc G4 with anticancer activity. TS-2 inhibits the growth of cancer cells and induces apoptosis of cancer cells by targeting the c-MYC oncogene promoter G4, causing transcriptional repression of the c-Myc oncogene[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Myc; G-quadruplex
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ts-2.html
Concentration
10mM
Purity
98.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[N+]1=C(SC=C1)/C=C/C2=CC(C3=C4C=CC=C3)=C(C=C2)N4C5=CC=CC=C5.[I-]
Molecular Formula
C24H19IN2S
Molecular Weight
494.39
References & Citations
[1]Rui Wang, et al. "Development of a fluorescent ligand that specifically binds to the c-MYC G-quadruplex by migrating the benzene group on a carbazole-benzothiazolium scaffold." Bioorganic Chemistry (2024) : 107690.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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