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SLU-PP-332

SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function[1].

Product Specifications

CAS Number

[303760-60-3]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/slu-pp-332.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CC=C2C=CC=CC2=C1)C3=CC=C(O)C=C3

Molecular Formula

C18H14N2O2

Molecular Weight

290.32

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Billon C, et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18 (4) :756-771.|[2]Nasri H. New hopes on" SLU-PP-332" as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view[J]. Journal of Renal Endocrinology, 2024, 10 (1) : e25143-e25143.|[3]Billon C, et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2024 Jan 17;388 (2) :232-240.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERRα; ERRβ; ERRγ

Available Sizes

Curated Selection

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