N1-Methylpseudouridine-5′-triphosphate (trisodium) solution (100mM)

N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100mM) is a nucleobase-modified nucleotide. N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100mM) is used for synthesizing mRNA with reduced immunogenicity and improved stability[1].

Product Specifications

Product Name Alternative

1-Methylpseudouridine-5′-triphosphate (trisodium) ; N1-Me-Pseudo UTP (trisodium) ; N1-Methyl-Pseudo-UTP (trisodium)

UNSPSC

12352200

Target

Biochemical Assay Reagents; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n1-methylpseudouridine-5-triphosphate-trisodium.html

Concentration

100 mM * 1 mL in water

Purity

99.70

Solubility

H2O : ≥ 125 mg/mL

Smiles

O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H14N2Na3O15P3

Molecular Weight

564.11

References & Citations

[1]Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N (1) -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.