BRM/BRG1 ATP Inhibitor-1

BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM) /SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1) /SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity[1].

Product Specifications

CAS Number

[2270879-17-7]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brm-brg1-atp-inhibitor-1.html

Purity

99.72

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC(NC(NC2=CC(C(F)F)=NS2)=O)=C(CO)C=N1

Molecular Formula

C11H9F3N4O2S

Molecular Weight

318.27

References & Citations

[1]Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM) /SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1) /SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61 (22) :10155-10172