LDN-193189 (dihydrochloride)
Product Specifications
Product Name Alternative
DM-3189 (dihydrochloride)
UNSPSC Description
LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].
Target Antigen
Organoid; TGF-β Receptor
Type
Reference compound
Related Pathways
Stem Cell/Wnt;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldn-193189-dihydrochloride.html
Purity
99.75
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 11.11 mg/mL (ultrasonic)
Smiles
C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16.Cl.Cl
Molecular Weight
479.40
References & Citations
[1]Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14(12), 1363-1369.|[2]Daniel Horbelt, et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 2015 Feb 6;290(6):3390-404.|[3]Julien Vollaire, et al. The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice. Front Pharmacol. 2019 Jun 19;10:667.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12071B/LDN-193189-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12071B/LDN-193189-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1435934-00-1
Available Sizes
Curated Selection
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