Choline (bitartrate)

Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2]. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism[3].

Product Specifications

CAS Number

[87-67-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; mAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/choline-bitartrate.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 55 mg/mL (ultrasonic) |H2O : 120 mg/mL (ultrasonic)

Smiles

OCC[N+](C)(C)C.O=C(O)[C@H](O)[C@@H](O)C([O-])=O

Molecular Formula

C9H19NO7

Molecular Weight

253.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Hollenbeck CB, et al. An introduction to the nutrition and metabolism of choline. Cent Nerv Syst Agents Med Chem. 2012 Jun;12 (2) :100-13.|[2]Corbin KD, et al. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012 Mar;28 (2) :159-65.|[3]Shinobu Kuwae, et al. Development of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content. Cytotechnology. 2018 Jun;70 (3) :939-948.|[4]Rebecca C Schugar, et al. Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. PLoS One. 2013 Aug 29;8 (8) :e74806.