DuP-532
DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl (hetero) arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction[1].
Product Specifications
CAS Number
[124750-95-4]
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dup-532.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C(F)(C(F)(F)F)F)N=C(CCC)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)O
Molecular Formula
C23H19F5N6O2
Molecular Weight
506.43
References & Citations
[1]A class of effective decarboxylative perfluoroalkylating reagents: [ (phen) 2Cu] (O2CRF)
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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