Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [PSH08-83]
Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. In Parkinson's disease and other synucleinopathies, insoluble forms of alpha-synuclein accumulate as inclusions in Lewy bodies. Familial Parkinson's disease is associated with mutations in the -synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids.
Product Specifications
Product Name Alternative
Abbreviation
Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor (NACP) SNCA NACP, PARK1
Swiss Prot
P37840 Human, O55042 Mouse, P37377 Rat
Cellular Locus
Cytoplasm, Membrane, Nucleus, Synapse, Secreted, Cell projection, axon.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human Alpha-Synuclein aa 1-140.
Isotype
IgG
Clone
PSH08-83
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IHC-Fr, IF-Tissue
Positive Control
Mouse cerebellum tissue, rat cerebellum tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;IHC-P: 1:5,000 ;IHC-Fr: 1:500 ;IF-Tissue: 1:500-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 14 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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