Thymine
Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 μM, Ki of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg[1].
Product Specifications
CAS Number
[65-71-4]
UNSPSC
12352005
Hazard Statement
H319
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5-Methylpyrimidine-2,4_1H,3H_-dione.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O=C1NC(C(C)=CN1)=O
Molecular Formula
C5H6N2O2
Molecular Weight
126.11
Precautions
H319
References & Citations
[1]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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