Thalidomide-NH-C9-NH2 (hydrochloride)
Thalidomide-NH-C9-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[2305936-77-8]
UNSPSC
12352005
Hazard Statement
H360
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-c9-nh2-hydrochloride.html
Purity
99.85
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCCCCCCCCN)=CC=C3)=O)=O.Cl
Molecular Formula
C22H31ClN4O4
Molecular Weight
450.96
Precautions
H360
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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