Aristolochic acid D

Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases[1][2][3][4][5][6].

Product Specifications

CAS Number

[17413-38-6]

Product Name Alternative

Aristolochic acid-IVa

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H341, H351

Target

CDK; Interleukin Related; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aristolochic-acid-d.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C([N+]([O-])=O)=CC3=C(OC)C=C(O)C=C3C2=C(OCO4)C4=C1)O

Molecular Formula

C17H11NO8

Molecular Weight

357.27

Precautions

H301+H311+H331, H341, H351

References & Citations

[1]Kupchan SM, et al. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. J Org Chem. 1968 Oct;33 (10) :3735-8.|[2]Balachandran P, et al. Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int. 2005 May;67 (5) :1797-805.|[3]Liu W, et al. Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice. J Nat Med. 2023 Mar;77 (2) :251-261.|[4]Gao QW, et al. Aristolochic acid IVa ameliorates arthritis in SKG Mice by regulating macrophage polarization and Th17/Treg balance. Phytomedicine. 2025 Apr;139:156557.|[5]Song, GQ, et al. Inhibitors of phosphodiesterase 2 activity. CN116898835A. 2023-10-20.|[6]Hegde VR, et al. Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. Bioorg Med Chem Lett. 2010 Feb 15;20 (4) :1384-7.