Transketolase-IN-4

Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM) . Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].

Product Specifications

CAS Number

[419547-73-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/transketolase-in-4.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(CC2=CC=CC=C2)NC3=C(C4=CC=C(C=C4)Cl)C=NN13

Molecular Formula

C19H14ClN3O

Molecular Weight

335.79

Precautions

H302, H315, H319

References & Citations

[1]Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9 (5) :427-33.|[2]Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18 (19) :5320-3.