PI3K/AKT-IN-1
PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively) . PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis[1].
Product Specifications
CAS Number
[3033069-84-7]
UNSPSC
12352005
Target
Akt; Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-akt-in-1.html
Purity
99.64
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=C(N/N=C/C2=CC(OC)=C(OC)C(OC)=C2)N=C(SC)N=C1C3=CC=C(OC)C=C3
Molecular Formula
C23H23N5O4S
Molecular Weight
465.52
References & Citations
[1]El-Dydamony NM, et al. Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562. J Enzyme Inhib Med Chem. 2022;37 (1) :895-911.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ; PI3Kδ
Available Sizes
Curated Selection
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