IRAK-4 protein kinase inhibitor 2

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].

Product Specifications

CAS Number

[301675-24-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/irak-4-protein-kinase-inhibitor-2.html

Concentration

10mM

Purity

98.01

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC([N+]([O-])=O)=C3

Molecular Formula

C14H10N4O3

Molecular Weight

282.25

Precautions

H315, H319, H320

References & Citations

[1]Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16 (11) :2842-5.