Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Nomifensine

Nomifensine ((±) -Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research[1][2][3][4][5][6][7].

Product Specifications

CAS Number

24526-64-5

Product Name Alternative

(±) -Nomifensine; Nomifensin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nomifensine.html

Concentration

10mM

Purity

98.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3

Molecular Formula

C16H18N2

Molecular Weight

238.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44 (5) :1615-22.|[2]Tuomisto J. Nomifensine and its derivatives as possible tools for studying amine uptake. Eur J Pharmacol. 1977 Mar 21;42 (2) :101-6. |[3]Tejani-Butt S, et al. Strain-dependent modification of behavior following antidepressant treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27 (1) :7-14. |[4]Katz NS, et al. Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J Psychopharmacol. 2010 Aug;24 (8) :1223-35.|[5]Kang SH, et al. Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells. Exp Ther Med. 2022 Apr;23 (4) :306.|[6]Gilbert AK, et al. Characterization of the analgesic properties of nomifensine in rats. Pharmacol Biochem Behav. 2001 Apr;68 (4) :783-7.|[7]Melamed E, et al. Suppression of MPTP-induced dopaminergic neurotoxicity in mice by nomifensine and L-DOPA. Brain Res. 1985 Sep 9;342 (2) :401-4.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

BioRxiv. 2024 June 12.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Glia. 2017 Aug;65 (8) :1251-1263.|Neurosci Lett. 2025 Sep 3:866:138373.|bioRxiv. 2023 Aug 3.|Commun Biol. 2021 Sep 13;4 (1) :1065.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

S100A4 (Marker of Tumor Metastasis) (S100A4/2750R), CF594 conjugate, 0.1mg/mL
BNC942750-100 1x 100 µL

S100A4 (Marker of Tumor Metastasis) (S100A4/2750R), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
DBCO-PEG5-NHS Ester
4526-AAT 1 mg

DBCO-PEG5-NHS Ester

Sign In for Pricing
View Details
DISC1 (NM_018662) Human Over-expression Lysate
LC402701 20 µg

DISC1 (NM_018662) Human Over-expression Lysate

Sign In for Pricing
View Details
Canine Coagulation Factor VIII (F8) ELISA Kit
RDR-F8-c-01 96 Tests

Canine Coagulation Factor VIII (F8) ELISA Kit

Sign In for Pricing
View Details
Canine Coagulation Factor VIII (F8) ELISA Kit
RDR-F8-c-02 48 Tests

Canine Coagulation Factor VIII (F8) ELISA Kit

Sign In for Pricing
View Details
GPX1 Rabbit Monoclonal Antibody [Clone ID: 24GB4425]
TA424816 100 µL

GPX1 Rabbit Monoclonal Antibody [Clone ID: 24GB4425]

Sign In for Pricing
View Details