Succinamic acid

Succinamic acid is a weak inhibitor for human LL-xylose reductase with an IC50 of 1.45 mM. Succinamic acid can be used as a linker for synthesis of CQ-16 (HY-169336) [1][2].

Product Specifications

CAS Number

[638-32-4]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/succinamic-acid.html

Purity

97.0

Smiles

O=C(O)CCC(N)=O

Molecular Formula

C4H7NO3

Molecular Weight

117.10

Precautions

H315, H319, H335

References & Citations

[1]Carbone V, et al., Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking. Bioorg Med Chem. 2005 Jan 17;13 (2) :301-12.|[2]Chen Q, et al., A Prostate-Specific Membrane Antigen-Targeting Small Molecule-Drug Conjugate Strategy to Overcome the Hematological Toxicity of Olaparib. J Med Chem. 2024 Nov 14;67 (21) :19586-19611.