Human WISP-1 (Highly Pure Recombinant)

<strong>Human WISP-1 (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010376_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human WISP-1 (Highly Pure) expressed in CHO. This protein acts as a WNT-inducible secreted protein that promotes angiogenesis in cancers._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuWISP-1; WNT1-inducible-signaling pathway protein 1; CCN4_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Meyers CA, Xu J, Asatrian G, Ding C, Shen J, Broderick K, Ting K, Soo C,_x000D_ Peault B, James AW. WISP-1 drives bone formation at the expense of fat formation_x000D_ in human perivascular stem cells. Sci Rep. 2018 Oct 23;8(1):15618._x000D_ _x000D_ 2: Tsai HC, Tzeng HE, Huang CY, Huang YL, Tsai CH, Wang SW, Wang PC, Chang AC,_x000D_ Fong YC, Tang CH. WISP-1 positively regulates angiogenesis by controlling VEGF-A_x000D_ expression in human osteosarcoma. Cell Death Dis. 2017 Apr 13;8(4):e2750._x000D_ _x000D_ 3: Chang AC, Chen PC, Lin YF, Su CM, Liu JF, Lin TH, Chuang SM, Tang CH._x000D_ Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone_x000D_ via the VCAM-1/integrin α4β1 system. Cancer Lett. 2018 Jul 10;426:47-56._x000D_ _x000D_ 4: Li FJ, Wang XJ, Zhou XL. WISP-1 overexpression upregulates cell proliferation_x000D_ in human salivary gland carcinomas via regulating MMP-2 expression. Onco Targets_x000D_ Ther. 2016 Oct 21;9:6539-6548._x000D_ _x000D_ 5: Hou CH, Chiang YC, Fong YC, Tang CH. WISP-1 increases MMP-2 expression and_x000D_ cell motility in human chondrosarcoma cells. Biochem Pharmacol. 2011 Jun_x000D_ 1;81(11):1286-95._x000D_ _x000D_ 6: Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R,_x000D_ O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia_x000D_ PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A. Macrophage-_x000D_ derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin_x000D_ Invest. 2017 Sep 1;127(9):3510-3520._x000D_ _x000D_ 7: Lin CC, Chen PC, Lein MY, Tsao CW, Huang CC, Wang SW, Tang CH, Tung KC._x000D_ WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in_x000D_ human oral squamous cell carcinoma cells. Oncotarget. 2016 Mar_x000D_ 1;7(9):9993-10005._x000D_ _x000D_ 8: Wright LH, Herr DJ, Brown SS, Kasiganesan H, Menick DR. Angiokine Wisp-1 is_x000D_ increased in myocardial infarction and regulates cardiac endothelial signaling._x000D_ JCI Insight. 2018 Feb 22;3(4):e95824._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31546898/">9: Kovács B, Vajda E, Nagy EE. Regulatory Effects and Interactions of the Wnt_x000D_ and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis._x000D_ Int J Mol Sci. 2019 Sep 19;20(18):4653. </a>_x000D_ _x000D_ <strong>Products Related to Human WISP-1 (Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>