Hematein

Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].

Product Specifications

CAS Number

[475-25-2]

UNSPSC

12352005

Target

Akt; Apoptosis; Casein Kinase; Wnt

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hematein.html

Purity

65.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O

Molecular Formula

C16H12O6

Molecular Weight

300.26

References & Citations

[1]Shirai, K., & Matsuoka, M. (1996) . Structure and properties of hematein derivatives. Dyes and Pigments, 32 (3), 159–169.|[2]Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43 (5) :1517-22.