Hematein
Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
Product Specifications
CAS Number
[475-25-2]
UNSPSC
12352005
Target
Akt; Apoptosis; Casein Kinase; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hematein.html
Purity
65.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O
Molecular Formula
C16H12O6
Molecular Weight
300.26
References & Citations
[1]Shirai, K., & Matsuoka, M. (1996) . Structure and properties of hematein derivatives. Dyes and Pigments, 32 (3), 159–169.|[2]Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43 (5) :1517-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2
Available Sizes
Curated Selection
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