Fexaramine

Fexaramine is a potent and selective FXR agonist with an EC50 of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors[1][2].

Product Specifications

CAS Number

[574013-66-4]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Autophagy; FXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Fexaramine.html

Purity

99.20

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC=C(C2=CC=C(CN(C3=CC(/C=C/C(OC)=O)=CC=C3)C(C4CCCCC4)=O)C=C2)C=C1

Molecular Formula

C32H36N2O3

Molecular Weight

496.64

Precautions

H302, H413

References & Citations

[1]Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP) . Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297 (1) :G90-7.|[2]Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21 (2) :159-65.|[3]Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11 (4) :1079-92.