IBG1

IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM) . IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139) ; Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495) ) [1][2].

Product Specifications

CAS Number

[2684292-71-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Epigenetic Reader Domain; Molecular Glues

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-brd4-degrader-19.html

Purity

98.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C)SC2=C1C(C3=CC=C(C4=CC=C(C=C4)C(NCC5=CC=C(C=C5)S(NC6=C7C(C(C#N)=CN7)=C(C=C6)C)(=O)=O)=O)C=C3)=N[C@@H](CC(OC)=O)C8=NN=C(C)N28

Molecular Formula

C44H38N8O5S2

Molecular Weight

822.95

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Ohba Kiyomi, et al. Medicine containing BRD4 protein degradation inducer. JP2023024381. |[2]Hsia O, et al. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024 Mar;627 (8002) :204-211.