Curcumin-d6

"Labelled Curcumin . A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope." "Srinivasan, et al, : J, Pharm, Pharmacol, , 5, 448 (1953), Tu, B, , et al, : J , Cell Biol, , 164, 341 (2004), Xu, G, , et al, : Biochemistry, 44, 9817"

Curcumin-d6 is supplied with detailed characterization data compliant with regulatory guideline. Curcumin-d6 can be used for analytical method development, method validation (AMV), Quality Control (QC) application for Abbreviated New Drug Application (ANDA), or during commercial production of Curcumin.

"Labelled Curcumin . A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope." "Srinivasan, et al, : J, Pharm, Pharmacol, , 5, 448 (1953), Tu, B, , et al, : J , Cell Biol, , 164, 341 (2004), Xu, G, , et al, : Biochemistry, 44, 9817"