Human Nt-3 Growth Factor Receptor, NTRK3 ELISA Kit

NT-3 growth factor receptor is also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudate-putamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4. In the PNS, The trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signaling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in the TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas, and other cancers. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

Concentration | O.D. | Average | Corrected ------------------------------------------ 4000 pg/ml | 2.426 | 2.515 | 2.388 2.603 2000 pg/ml | 1.217 | 1.224 | 1.097 1.23 1000 pg/ml | 0.631 | 0.623 | 0.496 0.615 500 pg/ml | 0.368 | 0.35 | 0.223 0.331 250 pg/ml | 0.23 | 0.232 | 0.105 0.233 125 pg/ml | 0.172 | 0.177 | 0.05 0.181 62.5 pg/ml | 0.151 | 0.143 | 0.016 0.134 0 pg/ml | 0.12 | 0.127 | 0 0.133

Intra/Inter-Assay | Sample | n | Mean | Standard Deviation | CV% ---------------------------------------------------------------- Intra-assay | 1 | 20 | 384 | 26.8 | 7 Intra-assay | 2 | 20 | 1202 | 42.6 | 3.5 Intra-assay | 3 | 20 | 3162 | 155 | 4.9 Inter-assay | 1 | 20 | 385 | 23.4 | 6.1 Inter-assay | 2 | 20 | 1204 | 59.9 | 5 Inter-assay | 3 | 20 | 3127 | 175 | 5.6

Components | Quantity --------------------- Pre-coated ELISA Plate | 12 x 8 well strips x 1 Standard Solution | 0.2mL x 1 vail Dilution Buffer | 20mL x 1 vail Stop Solution | 6mL x 1 vail Substrate Solution A | 12mL x 1 vail Substrate Solution B | 12mL x 1 vail Wash Buffer Concentrate (25x) | 20mL x 1 vail Detection Antibody Concentrate | 0.6mL x 1 vail