κ-Bungarotoxin
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC50 of 2.30 nM[1].
Product Specifications
CAS Number
[124511-67-7]
Product Name Alternative
κ-Bgt
UNSPSC
12352209
Target
NAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/κ-bungarotoxin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(NC(C(NC(C(N[C@H](C(NC(C(N1C(C(NC(C(NC(C(N[C@H](C(N2C(C(NC(C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4[C@H](CC)C)=O)CC(O)=O)=O)CCC(N)=O)=O)=O)CC(N)=O)=O)CCC3)=O)CSSCC(N5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC(C)C)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CC8=CC=C(O)C=C8)=O)CC(N)=O)=O)CO)=O)CCCNC(N)=N)=O)CC9=CC=CC=C9)=O)CCC(N)=O)=O)CCC6)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%10CC(N)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CC%11=CNC=N%11)=O)CC(N)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)C(C)C)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CCC2)=O)[C@@H](C)O)=O)CO)=O)CO)=O)CCC1)=O)CO)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC4=O)C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@H](C(NC(C(NC(C(NC%12CC%13=CC=CC=C%13)=O)CCCCN)=O)CC(O)=O)=O)CSSC[C@H](NC%12=O)C(NC(C(N[C@H](C(NC(C(NCC(N%14C(C(NC(C(N[C@H](C(NC(C(NC(C(NCC5=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CCC%14)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CO)=O)=O)CCC(N)=O)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC%15=CC=CC=C%15)=O)=O)[C@@H](C)O
Molecular Formula
C303H475N91O97S10
Molecular Weight
7265.22
References & Citations
[1]Grant GA, et al. Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist. Biochemistry. 1998 Sep 1;37 (35) :12166-71.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5833/κ-Bungarotoxin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5833/
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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