κ-Bungarotoxin

κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC50 of 2.30 nM[1].

Product Specifications

CAS Number

[124511-67-7]

Product Name Alternative

κ-Bgt

UNSPSC

12352209

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/κ-bungarotoxin.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(NC(C(NC(C(N[C@H](C(NC(C(N1C(C(NC(C(NC(C(N[C@H](C(N2C(C(NC(C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4[C@H](CC)C)=O)CC(O)=O)=O)CCC(N)=O)=O)=O)CC(N)=O)=O)CCC3)=O)CSSCC(N5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC(C)C)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CC8=CC=C(O)C=C8)=O)CC(N)=O)=O)CO)=O)CCCNC(N)=N)=O)CC9=CC=CC=C9)=O)CCC(N)=O)=O)CCC6)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%10CC(N)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CC%11=CNC=N%11)=O)CC(N)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)C(C)C)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CCC2)=O)[C@@H](C)O)=O)CO)=O)CO)=O)CCC1)=O)CO)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC4=O)C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@H](C(NC(C(NC(C(NC%12CC%13=CC=CC=C%13)=O)CCCCN)=O)CC(O)=O)=O)CSSC[C@H](NC%12=O)C(NC(C(N[C@H](C(NC(C(NCC(N%14C(C(NC(C(N[C@H](C(NC(C(NC(C(NCC5=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CCC%14)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CO)=O)=O)CCC(N)=O)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC%15=CC=CC=C%15)=O)=O)[C@@H](C)O

Molecular Formula

C303H475N91O97S10

Molecular Weight

7265.22

References & Citations

[1]Grant GA, et al. Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist. Biochemistry. 1998 Sep 1;37 (35) :12166-71.