4-Chlorophenylacetic acid

4-Chlorophenylacetic acid is a halogenated phenylacetic acid derivative. 4-Chlorophenylacetic acid is a potent aromatase inhibitor and antagonizes estrogen signaling. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp. strain CBS3. 4-Chlorophenylacetic acid is effective against estrogen-induced mammary tumorigenesis[1][2].

Product Specifications

CAS Number

[1878-66-6]

UNSPSC

12352005

Hazard Statement

H312+H332

Target

Cytochrome P450; Drug Derivative; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-chlorophenylacetic-acid.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(=O)CC1=CC=C(Cl)C=C1

Molecular Formula

C8H7ClO2

Molecular Weight

170.59

Precautions

H312+H332

References & Citations

[1]U Klages, et al. Degradation of 4-chlorophenylacetic Acid by a Pseudomonas Species. J Bacteriol. 1981 Apr;146 (1) :64-8.|[2]Aputen, A. D., et al., (2022) . Bioactive Platinum (IV) Complexes Incorporating Halogenated Phenylacetates. Molecules (Basel, Switzerland), 27 (20), 7120.