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Venadaparib (IDX-1197)

Product Specifications

CAS Number

1681017-83-3

Target

PARP

Applications

DNA Damage/DNA Repair

Smiles

FC1=C (C=C (CC2=NNC (=O) C3=CC=CC=C23) C=C1) C (=O) N4CC (CNC5CC5) C4

Molecular Formula

C23H23FN4O2

Additionnal Information

Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.

Storage Conditions

3 years -20°C powder

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