Tuxobertinib (BDTX-189)
Product Specifications
CAS Number
2414572-47-5
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
ClC1=C (OCC2=NC=CC=C2) C=CC (=C1) NC3=NC=NC4=C3C=C (NC (=O) C=C) C (=C4) OCCN5CCOCC5
Molecular Formula
C29H29ClN6O4
Additionnal Information
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
Storage Conditions
3 years -20°C powder
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