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Farudodstat

Product Specifications

CAS Number

1035688-66-4

Synonyms

LAS 186323, ASLAN003

Target

Dehydrogenase

Applications

Metabolism

Smiles

COC1=CC=CC (=C1) C2=CC (=C (NC3=NC=CC=C3C (O) =O) C (=C2) F) F

Molecular Formula

C19H14F2N2O3

Additionnal Information

Farudodstat (LAS 186323, ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.

Storage Conditions

3 years -20°C powder

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