Farudodstat
Product Specifications
CAS Number
1035688-66-4
Synonyms
LAS 186323, ASLAN003
Target
Dehydrogenase
Applications
Metabolism
Smiles
COC1=CC=CC (=C1) C2=CC (=C (NC3=NC=CC=C3C (O) =O) C (=C2) F) F
Molecular Formula
C19H14F2N2O3
Additionnal Information
Farudodstat (LAS 186323, ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.
Storage Conditions
3 years -20°C powder
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