MLi-2
Product Specifications
CAS Number
1627091-47-7
Target
LRRK2
Applications
Autophagy
Smiles
CC1CN (CC (C) O1) C2=CC (=NC=N2) C3=N[NH]C4=CC=C (OC5 (C) CC5) C=C34
Molecular Formula
C21H25N5O2
Additionnal Information
MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM.
Storage Conditions
3 years -20°C powder
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