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GSK046 (iBET-BD2)

Product Specifications

CAS Number

2474876-09-8

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

CC (OC1=CC (=CC (=C1NC (C) =O) F) C (=O) NC2CCC (O) CC2) C3=CC=CC=C3

Molecular Formula

C23H27FN2O4

Additionnal Information

GSK046 (iBET-BD2) is a selective and orally active inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2, respectively. GSK046 exhibits immunomodulatory activity.

Storage Conditions

3 years -20°C powder

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