Remibrutinib
Product Specifications
CAS Number
1787294-07-8
Synonyms
LOU064
Target
Interleukins
Applications
Immunology & Inflammation
Smiles
CC1=C (C=C (C=C1NC (=O) C2=C (C=C (C=C2) C3CC3) F) F) C4=C (C (=NC=N4) N) OCCN (C) C (=O) C=C
Molecular Formula
C27H27F2N5O3
Additionnal Information
Remibrutinib is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
Storage Conditions
3 years -20°C powder
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